The expression of the imprinted H19 and IGF‐2 genes in human bladder carcinoma

199588 citationsJournal Articlebronze Open Access

Authors

Michael Elkin · Hebrew University of Jerusalem

Alexander Shevelev · Case Western Reserve University

Ekkehard Schulze · Case Western Reserve University

Mark Tykocinsky · Case Western Reserve University

Mark J. Cooper · Case Western Reserve University

Ilana Ariel · Hadassah Academic College

Dov Pode

Abstract

The imprinted H19 gene is highly expressed in human embryos, fetal tissues and is nearly completely shut off in adults. However, it is reexpressed in a number of tumors including bladder carcinoma, demonstrating that H19 RNA is an oncofetal RNA. Tumors induced by injection of bladder carcinoma cell lines express H19 in contrast to the cells before injection. These observations support the notion of a positive correlation between H19 expression and bladder carcinoma. Loss of imprinting of H19 and IGF-2 was observed in samples of human bladder carcinoma.

Topics & Keywords

Genetic Syndromes and Imprinting Cancer-related molecular mechanisms research RNA modifications and cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: FEBS Letters

Volume 374, Issue 1, pp. 57-61

DOI: 10.1016/0014-5793(95)01074-o

Field-Weighted Citation Impact: 2.44