The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma

20031,498 citationsJournal Articlebronze Open Access

Authors

Erming Tian

Fenghuang Zhan

Ronald C. Walker · University of Arkansas for Medical Sciences

Erik Rasmussen · Cancer Research And Biostatistics

Yupo Ma · University of Arkansas for Medical Sciences

Bart Barlogie

John D. Shaughnessy

Abstract

The production of DKK1, an inhibitor of osteoblast differentiation, by myeloma cells is associated with the presence of lytic bone lesions in patients with multiple myeloma.

Topics & Keywords

Multiple Myeloma Research and Treatments Bone health and treatments Peptidase Inhibition and Analysis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 349, Issue 26, pp. 2483-2494

DOI: 10.1056/nejmoa030847

Field-Weighted Citation Impact: 24.73