COPD Results in a Reduction in UCP3 Long mRNA and UCP3 Protein Content in Types I and IIa Skeletal Muscle Fibers

The reduced UCP3 and IMTG content in the more oxidative fibers may be linked to the altered muscle fatty acid metabolism associated with COPD. Further studies are required to determine the exact role and clinical relevance of the reduced UCP3 content in patients with COPD.