miR-638 mediated regulation of BRCA1affects DNA repair and sensitivity to UV and cisplatin in triple-negative breast cancer

2014112 citationsJournal Articlegold Open Access

Authors

Xiaohui Tan · George Washington University

Jin Peng · George Washington University

Yebo Fu · George Washington University

Shejuan An · George Washington University

Katayoon Rezaei · George Washington University

Sana Tabbara · George Washington University

Christine Teal ·

Abstract

Our findings suggest that miR-638 plays an important role in TNBC progression via BRCA1 deregulation. Therefore, miR-638 might serve as a potential prognostic biomarker and therapeutic target for breast cancer.

Topics & Keywords

MicroRNA in disease regulation Circular RNAs in diseases Cancer-related molecular mechanisms research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Breast Cancer Research

Volume 16, Issue 5, pp. 435-435

DOI: 10.1186/s13058-014-0435-5

Field-Weighted Citation Impact: 5.55