Cancer Risk in Diabetic Patients Treated with Metformin: A Systematic Review and Meta-analysis

2012563 citationsReviewgold Open Access

Authors

Hiroshi Noto · National Center for Global Health and Medicine

Atsushi Goto · National Center for Global Health and Medicine

Tetsuro Tsujimoto · National Center for Global Health and Medicine

Mitsuhiko Noda · National Center for Global Health and Medicine

Abstract

The use of metformin in diabetic patients was associated with significantly lower risks of cancer mortality and incidence. However, this analysis is mainly based on observational studies and our findings underscore the more need for long-term RCTs to confirm this potential benefit for individuals with diabetes.

Topics & Keywords

Metabolism, Diabetes, and Cancer Diabetes Treatment and Management Pancreatic and Hepatic Oncology Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 7, Issue 3, pp. e33411-e33411

DOI: 10.1371/journal.pone.0033411

Field-Weighted Citation Impact: 27.71