Aldo-keto reductase-7A protects liver cells and tissues from acetaminophen-induced oxidative stress and hepatotoxicity

201156 citationsJournal Articlebronze Open Access

Authors

Munzir M. E. Ahmed · Gadarif University

Tao Wang · Xiamen University

Yu Luo · Army Medical University

Shuilong Ye · Third Hospital of Changsha

Qiao Wu · Xiamen University

Zongsheng Guo · Xiamen University

Bill D. Roebuck · Dartmouth College

Abstract

AKR7A proteins are significantly up-regulated in response to APAP/NAPQI exposure to contribute significantly to protection against APAP-induced hepatotoxicity. AKR7A mediates this protection, in part, through enhancing hepatocellular antioxidant defense.

Topics & Keywords

Aldose Reductase and Taurine Genomics, phytochemicals, and oxidative stress Cannabis and Cannabinoid Research

Publication Details

Published in: Hepatology

Volume 54, Issue 4, pp. 1322-1332

DOI: 10.1002/hep.24493

Field-Weighted Citation Impact: 1.91

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Aldo-keto reductase-7A protects liver cells and tissues from acetaminophen-induced oxidative stress and hepatotoxicity

Authors

Abstract

Topics & Keywords

Publication Details