Triazole Fungicides Can Induce Cross-Resistance to Medical Triazoles in Aspergillus fumigatus

2012417 citationsJournal Articlegold Open Access

Authors

Eveline Snelders · Radboud University Nijmegen

Simone M. T. Camps · Radboud University Nijmegen

Anna Karawajczyk · Radboud University Nijmegen

Gijs Schaftenaar · Radboud Institute for Molecular Life Sciences

G.H.J. Kema

Henrich A. van der Lee · Radboud University Nijmegen

Corné H. W. Klaassen · Canisius-Wilhelmina Ziekenhuis

Abstract

Our findings support a fungicide-driven route of TR(34)/L98H development in A. fumigatus. Similar molecule structure characteristics of five triazole DMIs and the three medical triazoles appear the underlying mechanism of cross resistance development. Our findings have major implications for the assessment of health risks associated with the use of triazole DMIs.

Topics & Keywords

Fungal Plant Pathogen Control Antifungal resistance and susceptibility Fungal and yeast genetics research

Publication Details

Published in: PLoS ONE

Volume 7, Issue 3, pp. e31801-e31801

DOI: 10.1371/journal.pone.0031801

Field-Weighted Citation Impact: 47.28

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Triazole Fungicides Can Induce Cross-Resistance to Medical Triazoles in Aspergillus fumigatus

Authors

Abstract

Topics & Keywords

Publication Details