Prenatal Exposure to Organophosphates, Paraoxonase 1, and Cognitive Development in Childhood

2011389 citationsJournal Articlediamond Open Access

Authors

Stephanie M. Engel · General Department of Preventive Medicine

James G. Wetmur · Icahn School of Medicine at Mount Sinai

Jia Chen · General Department of Preventive Medicine

Chenbo Zhu · General Department of Preventive Medicine

Dana Boyd Barr · Emory University

Richard L. Canfield · Cornell University

Mary S. Wolff

Abstract

Our findings suggest that prenatal exposure to organophosphates is negatively associated with cognitive development, particularly perceptual reasoning, with evidence of effects beginning at 12 months and continuing through early childhood. PON1 may be an important susceptibility factor for these deleterious effects.

Topics & Keywords

Paraoxonase enzyme and polymorphisms Pesticide Exposure and Toxicity Childhood Cancer Survivors' Quality of Life

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Environmental Health Perspectives

Volume 119, Issue 8, pp. 1182-1188

DOI: 10.1289/ehp.1003183

Field-Weighted Citation Impact: 21.05