Phosphorylated TDP‐43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

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Authors

Masato Hasegawa · Tokyo Institute of Psychiatry

Tetsuaki Arai · Tokyo Institute of Psychiatry

Takashi Nonaka · Tokyo Institute of Psychiatry

Fuyuki Kametani · Tokyo Institute of Psychiatry

Mari Yoshida · Aichi Medical University

Yoshio Hashizume · Aichi Medical University

Thomas G. Beach

Abstract

These results suggest that phosphorylated TDP-43 is a major component of the inclusions, and that abnormal phosphorylation of TDP-43 is a critical step in the pathogenesis of FTLD-U and ALS. Phosphorylation-specific antibodies will be powerful tools for the investigation of these disorders.

Topics & Keywords

Amyotrophic Lateral Sclerosis Research Parkinson's Disease Mechanisms and Treatments Prion Diseases and Protein Misfolding

Publication Details

Published in: Annals of Neurology

Volume 64, Issue 1, pp. 60-70

DOI: 10.1002/ana.21425

Field-Weighted Citation Impact: 28.61

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Phosphorylated TDP‐43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Authors

Abstract

Topics & Keywords

Publication Details