Silencing of GPNMB by siRNA Inhibits the Formation of Melanosomes in Melanocytes in a MITF-Independent Fashion

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Authors

Ping Zhang · Air Force General Hospital PLA

Wei Liu · Xijing Hospital

Cansheng Zhu · Institute of Endemic Disease Control in Shandong Province

Xiao‐Ying Yuan · Air Force General Hospital PLA

Dongguang Li · Air Force General Hospital PLA

Weijie Gu · Air Force General Hospital PLA

Huimin Ma

Abstract

Our present work revealed that the GPNMB was critical for the formation of melanosomes. And GPNMB expression down-regulation attenuated melanosome formation in a MITF-independent fashion.

Topics & Keywords

melanin and skin pigmentation RNA regulation and disease Biochemical Analysis and Sensing Techniques

Publication Details

Published in: PLoS ONE

Volume 7, Issue 8, pp. e42955-e42955

DOI: 10.1371/journal.pone.0042955

Field-Weighted Citation Impact: 1.55

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Silencing of GPNMB by siRNA Inhibits the Formation of Melanosomes in Melanocytes in a MITF-Independent Fashion

Authors

Abstract

Topics & Keywords

Publication Details