Therapeutic Angiogenesis Induced by Human Hepatocyte Growth Factor Gene in Rat Diabetic Hind Limb Ischemia Model

2001166 citationsJournal Articlebronze Open Access

Authors

Yoshiaki Taniyama · YKK (Japan)

Ryuichi Morishita · Hitachi (Japan)

Kazuya Hiraoka · The University of Osaka

Motokuni Aoki · The University of Osaka

Hironori Nakagami · The University of Osaka

Keita Yamasaki · The University of Osaka

Kunio Matsumoto ·

Abstract

Overall, intramuscular injection of human HGF plasmid induced therapeutic angiogenesis in a rat diabetic ischemic hindlimb model as a potential therapy for peripheral arterial disease. The delay of angiogenesis in diabetes might be due to downregulation of MMP-1 and ets-1 through a decrease in HGF by high D-glucose.

Topics & Keywords

Liver physiology and pathology Angiogenesis and VEGF in Cancer Pancreatic function and diabetes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 104, Issue 19, pp. 2344-2350

DOI: 10.1161/hc4401.098470

Field-Weighted Citation Impact: 6.16