Tumour gene expression predicts response to cetuximab in patients with KRAS wild-type metastatic colorectal cancer

2011108 citationsJournal Articlehybrid Open Access

Authors

Joffre Baker · Genomic Health (United States)

Debjani Dutta · Genomic Health (United States)

Drew Watson · Genomic Health (United States)

Tara Maddala · Genomic Health (United States)

Brian Munneke · Genomic Health (United States)

S. Shak · Genomic Health (United States)

E.K. Rowinsky

Abstract

Gene expression appears to identify KRAS wt mCRC patients who receive little benefit from cetuximab. It will be important to test this model in an independent validation study.

Topics & Keywords

Colorectal Cancer Treatments and Studies Genetic factors in colorectal cancer Gastric Cancer Management and Outcomes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Cancer

Volume 104, Issue 3, pp. 488-495

DOI: 10.1038/sj.bjc.6606054

Field-Weighted Citation Impact: 7.18