Association between enhanced type I collagen expression and epigenetic repression of the <i>FLI1</i> gene in scleroderma fibroblasts

The results of this study indicate that epigenetic mechanisms may mediate the fibrotic manifestations of SSc. The signal transduction leading to the SSc fibrotic phenotype appears to converge on DNA methylation and histone deacetylation at the FLI1 gene.