Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression

20091,651 citationsReviewgreen Open Access

Authors

Neil Risch

Richard Herrell · National Institutes of Health

Thomas Lehner · National Institutes of Health

Kung‐Yee Liang · Johns Hopkins University

Lindon J. Eaves · Virginia Commonwealth University

Josephine Hoh · Yale University

Andrea Griem · National Institutes of Health

Abstract

This meta-analysis yielded no evidence that the serotonin transporter genotype alone or in interaction with stressful life events is associated with an elevated risk of depression in men alone, women alone, or in both sexes combined.

Topics & Keywords

Neurotransmitter Receptor Influence on Behavior Tryptophan and brain disorders Child and Adolescent Psychosocial and Emotional Development

UN Sustainable Development Goals

Reduced inequalities

Publication Details

Published in: JAMA

Volume 301, Issue 23, pp. 2462-2462

DOI: 10.1001/jama.2009.878

Field-Weighted Citation Impact: 84.18