Peripheral CLOCK Regulates Target-Tissue Glucocorticoid Receptor Transcriptional Activity in a Circadian Fashion in Man

2011138 citationsJournal Articlegold Open Access

Authors

Evangelia Charmandari · Biomedical Research Foundation of the Academy of Athens

George P. Chrousos · National and Kapodistrian University of Athens

George Ι. Lambrou · Children's Hospital Agia Sophia

Aikaterini N Pavlaki · National and Kapodistrian University of Athens

Hisashi Koide · Eunice Kennedy Shriver National Institute of Child Health and Human Development

Sinnie Sin Man Ng · National Institutes of Health

Abstract

Peripheral CLOCK-mediated circadian acetylation of the human GR may function as a target-tissue, gene-specific counter regulatory mechanism to the actions of diurnally fluctuating cortisol, effectively decreasing tissue sensitivity to glucocorticoids in the morning and increasing it at night.

Topics & Keywords

Circadian rhythm and melatonin Stress Responses and Cortisol Hormonal Regulation and Hypertension

Publication Details

Published in: PLoS ONE

Volume 6, Issue 9, pp. e25612-e25612

DOI: 10.1371/journal.pone.0025612

Field-Weighted Citation Impact: 4.93

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Peripheral CLOCK Regulates Target-Tissue Glucocorticoid Receptor Transcriptional Activity in a Circadian Fashion in Man

Authors

Abstract

Topics & Keywords

Publication Details