Functional Role of Inflammatory Cytokines and Antiinflammatory Molecules in Seizures and Epileptogenesis

2002382 citationsJournal Article

Authors

Annamaria Vezzani · Mario Negri Institute for Pharmacological Research

D. Moneta · Mario Negri Institute for Pharmacological Research

Cristina Richichi · Mario Negri Institute for Pharmacological Research

Marisa Aliprandi · Mario Negri Institute for Pharmacological Research

Stephanie J. Burrows · Mario Negri Institute for Pharmacological Research

Teresa Ravizza · Mario Negri Institute for Pharmacological Research

Abstract

This study shows that limbic seizures in rodents rapidly and reversibly induce proinflammatory cytokines in glia and suggests that changes in the IL-1Ra/IL-1beta ratio in brain may represent an effective physiopathologic mechanism to control seizures.

Topics & Keywords

Neuroscience and Neuropharmacology Research Neuroinflammation and Neurodegeneration Mechanisms Neonatal and fetal brain pathology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Epilepsia

Volume 43, Issue s5, pp. 30-35

DOI: 10.1046/j.1528-1157.43.s.5.14.x

Field-Weighted Citation Impact: 4.50