INTRACEREBRAL INFUSATE DISTRIBUTION BY CONVECTION-ENHANCED DELIVERY IN HUMANS WITH MALIGNANT GLIOMAS

2007126 citationsJournal Article

Authors

John H. Sampson · Center for Biologics Evaluation and Research

Martin Brady · Center for Biologics Evaluation and Research

Neil A. Petry · Center for Biologics Evaluation and Research

David Croteau · Center for Biologics Evaluation and Research

Allan H. Friedman · Center for Biologics Evaluation and Research

Henry S. Friedman · Center for Biologics Evaluation and Research

Abstract

CED has the potential to deliver high molecular weight agents into tumor-infiltrated brain parenchyma with volumes of distribution that are clinically relevant. Target tissue anatomy and catheter position are critical parameters in optimizing drug delivery.

Topics & Keywords

Glioma Diagnosis and Treatment Ultrasound and Hyperthermia Applications Traumatic Brain Injury and Neurovascular Disturbances

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Operative Neurosurgery

Volume 60, Issue 2, pp. 89-99

DOI: 10.1227/01.neu.0000249256.09289.5f

Field-Weighted Citation Impact: 6.70