A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal Cancer

2012258 citationsJournal Articlegold Open Access

Authors

Marina Antelo

Francesc Balaguer · Universitat de Barcelona

Jinru Shia · Memorial Sloan Kettering Cancer Center

Yan Shen · Baylor University Medical Center

Keun Hur · Baylor University Medical Center

Leticia Moreira · Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

Míriam Cuatrecasas · Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

Abstract

LINE-1 hypomethylation constitutes a potentially important feature of early-onset CRC, and suggests a distinct molecular subtype. Further studies are needed to assess the potential of LINE-1 methylation status as a prognostic biomarker for young people with CRC.

Topics & Keywords

Genetic factors in colorectal cancer Cholangiocarcinoma and Gallbladder Cancer Studies vaccines and immunoinformatics approaches

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 7, Issue 9, pp. e45357-e45357

DOI: 10.1371/journal.pone.0045357

Field-Weighted Citation Impact: 8.47