Major Depressive Disorder and Hypothalamic-Pituitary-Adrenal Axis Activity

2009765 citationsJournal Article

Authors

Sophie A. Vreeburg · Vrije Universiteit Amsterdam

Witte J.G. Hoogendijk · Vrije Universiteit Amsterdam

Johannes van Pelt · Leiden University

Roel H. DeRijk · Leiden University

Jolanda C. M. Verhagen · Leiden University

Richard van Dyck · Vrije Universiteit Amsterdam

Johannes H. Smit

Abstract

This large cohort study shows significant, although modest, associations between MDD and specific hypothalamic-pituitary-adrenal axis indicators. Because a higher cortisol awakening response was observed among both subjects with current MDD and subjects with remitted MDD, this may be indicative of an increased biological vulnerability for depression.

Topics & Keywords

Stress Responses and Cortisol Tryptophan and brain disorders Hormonal Regulation and Hypertension

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Archives of General Psychiatry

Volume 66, Issue 6, pp. 617-617

DOI: 10.1001/archgenpsychiatry.2009.50

Field-Weighted Citation Impact: 11.36