Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet

2006588 citationsJournal Article

Authors

Kristopher J. Bough · Emory University

Jonathon P. Wetherington · Emory University

Bjørnar Hassel · Norwegian Defence Research Establishment

Jean Francois Pare · Emory University

Jeremy W. Gawryluk · University of North Dakota

James G. Greene · Emory University

Reneé Shaw ·

Abstract

These data show that a calorie-restricted KD enhances brain metabolism. We propose an anticonvulsant mechanism of the KD involving mitochondrial biogenesis leading to enhanced alternative energy stores.

Topics & Keywords

Diet and metabolism studies Metabolism and Genetic Disorders Mitochondrial Function and Pathology

UN Sustainable Development Goals

Affordable and clean energy

Publication Details

Published in: Annals of Neurology

Volume 60, Issue 2, pp. 223-235

DOI: 10.1002/ana.20899

Field-Weighted Citation Impact: 7.92