A randomized comparison of intravenous heparin with oral aspirin and dipyridamole 24 hours after recombinant tissue-type plasminogen activator for acute myocardial infarction. National Heart Foundation of Australia Coronary Thrombolysis Group.

199185 citationsJournal Articlebronze Open Access

Authors

Pauline Thompson · Sir Charles Gairdner Hospital

Philip E. Aylward · Sir Charles Gairdner Hospital

J. Federman · Sir Charles Gairdner Hospital

R. Giles · Sir Charles Gairdner Hospital

Phillip J. Harris · Sir Charles Gairdner Hospital

RL Hodge · Sir Charles Gairdner Hospital

G. Nelson

Abstract

We conclude that heparin therapy can be discontinued 24 hours after rt-PA therapy and replaced with an oral antiplatelet regimen without any adverse effects on chest pain, reinfarction, coronary patency, or left ventricular function.

Topics & Keywords

Acute Myocardial Infarction Research Venous Thromboembolism Diagnosis and Management Protease and Inhibitor Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 83, Issue 5, pp. 1534-1542

DOI: 10.1161/01.cir.83.5.1534

Field-Weighted Citation Impact: 11.47