LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer

2013187 citationsJournal Articlehybrid Open Access

Authors

Jie Ding · Guizhou Provincial People's Hospital

Z-M Zhang · Guizhou Provincial People's Hospital

Xia Yi · Guizhou Provincial People's Hospital

Guoqing Liao · Xiangya Hospital Central South University

Yi Pan · Guizhou Provincial People's Hospital

Sheng Liu · Xiangya Hospital Central South University

Yu Zhang

Abstract

Lysine-specific demethylase 1 downregulates the expression of CDH-1 by epigenetic modification, and consequently promotes metastasis of colon cancer cells. The LSD1 antagonists might be a useful strategy to suppress metastasis of colon cancer.

Topics & Keywords

Epigenetics and DNA Methylation Cancer-related gene regulation Genetic Syndromes and Imprinting

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Cancer

Volume 109, Issue 4, pp. 994-1003

DOI: 10.1038/bjc.2013.364

Field-Weighted Citation Impact: 6.58