Using Ribosomal Protein Genes as Reference: A Tale of Caution

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Authors

Lieven Thorrez · KU Leuven

Katrijn Van Deun · KU Leuven

Léon-Charles Tranchevent · KU Leuven

Leentje Van Lommel · KU Leuven

Kristof Engelen · KU Leuven

Kathleen Marchal · KU Leuven

Yves Moreau · KU Leuven

Abstract

Here we provide statistical and biological evidence that ribosomal protein genes exhibit important tissue-dependent variation in mRNA expression. Though these genes are most stably expressed of all investigated genes in a meta-analysis they cannot be considered true reference genes.

Topics & Keywords

Molecular Biology Techniques and Applications RNA Research and Splicing Gene expression and cancer classification

Publication Details

Published in: PLoS ONE

Volume 3, Issue 3, pp. e1854-e1854

DOI: 10.1371/journal.pone.0001854

Field-Weighted Citation Impact: 5.79

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Using Ribosomal Protein Genes as Reference: A Tale of Caution

Authors

Abstract

Topics & Keywords

Publication Details