Enantiomer Separation by HPLC with Some Urea Derivatives of L-Valine as Novel Chiral Stationary Phases

Abstract Two novel chiral stationary phases derived from (R)- and (S)-1-(α-naphthyl)ethylamine with (S)-valine chemically bonded to γ-aminopropyl silanized silica, which contain two asymmetric carbon atoms attached to two nitrogen atoms of the urea group, have been prepared. These phases showed excellent enantioselectivity for derivatives of amino acid, amine, carboxylic acid and alcohol enantiomers. Some alcohol and ester enantiomers were well resolved directly without any prederivatization upon these phases.