<scp>IL</scp>‐33 drives airway hyper‐responsiveness through <scp>IL</scp>‐13‐mediated mast cell: airway smooth muscle crosstalk

2015162 citationsJournal Articlehybrid Open Access

Authors

Davinder Kaur · University of Leicester

E. Gomez · University of Leicester

Camille Doe · University of Leicester

Rachid Berair · University of Leicester

Lucy Woodman · University of Leicester

Ruth Saunders · University of Leicester

Fay Hollins · University of Leicester

Abstract

IL-33 directly promotes mast cell activation and ASM wound repair but indirectly promotes ASM contraction via upregulation of mast cell-derived IL-13. This suggests that IL-33 may present an important target to modulate mast cell-ASM crosstalk in asthma.

Topics & Keywords

IL-33, ST2, and ILC Pathways Eosinophilic Esophagitis Asthma and respiratory diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Allergy

Volume 70, Issue 5, pp. 556-567

DOI: 10.1111/all.12593

Field-Weighted Citation Impact: 6.51