Coexisting Polymorphisms of P2Y12 and CYP2C19 Genes as a Risk Factor for Persistent Platelet Activation With Clopidogrel

200895 citationsJournal Articlebronze Open Access

Authors

Łukasz A. Małek · Corona (Poland)

Bartłomiej Kisiel · Children’s Aid Society

Mateusz Śpiewak · Medical University of Warsaw

Marcin Grabowski · Medical University of Warsaw

Krzysztof J. Filipiak‬ · Medical University of Warsaw

Grażyna Kostrzewa · Medical University of Warsaw

Zenon Huczek

Abstract

Coexisting, rather then single, polymorphisms of different genes may be related to persistent platelet activation while on clopidogrel, which raises concern about harm in patients with ACS.

Topics & Keywords

Antiplatelet Therapy and Cardiovascular Diseases Venous Thromboembolism Diagnosis and Management Inflammatory mediators and NSAID effects

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Journal

Volume 72, Issue 7, pp. 1165-1169

DOI: 10.1253/circj.72.1165

Field-Weighted Citation Impact: 8.17