HLA Antibody Specification Using Single-Antigen Beads—A Technical Solution for the Prozone Effect

2011238 citationsJournal Article

Authors

M. Schnaidt · University of Tübingen

Christof Weinstock · German Red Cross

Marija Jurisic

Barbara D. Schmid-Horch

A. Ender · Katharinenhospital

Dorothee Wernet

Abstract

Our observations are consistent with the hypothesis that dissociation or destruction of complement C1 eliminates the prozone effect. Addition of EDTA to serum of highly immunized patients is the easiest way to avoid false-negative results in SAB testing caused by a prozone effect.

Topics & Keywords

Monoclonal and Polyclonal Antibodies Research Blood groups and transfusion Complement system in diseases

Publication Details

Published in: Transplantation

Volume 92, Issue 5, pp. 510-515

DOI: 10.1097/tp.0b013e31822872dd

Field-Weighted Citation Impact: 12.26

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HLA Antibody Specification Using Single-Antigen Beads—A Technical Solution for the Prozone Effect

Authors

Abstract

Topics & Keywords

Publication Details