Cloning of a Delta Opioid Receptor by Functional Expression

19921,224 citationsJournal Article

Authors

Christopher J. Evans · University of California, Los Angeles

Duane E. Keith · University of California, Los Angeles

Heather Morrison · University of California, Los Angeles

Karin Magendzo · University of California, Los Angeles

Robert H. Edwards · University of California, Los Angeles

Abstract

Opiate drugs have potent analgesic and addictive properties. These drugs interact with receptors that also mediate the response to endogenous opioid peptide ligands. However, the receptors for opioids have eluded definitive molecular characterization. By transient expression in COS cells and screening with an iodinated analog of the opioid peptide enkephalin, a complementary DNA clone encoding a functional delta opioid receptor has been identified. The sequence shows homology to G protein-coupled receptors, in particular the receptors for somatostatin, angiotensin, and interleukin-8.

Topics & Keywords

Neuropeptides and Animal Physiology Receptor Mechanisms and Signaling Pharmacological Receptor Mechanisms and Effects

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Science

Volume 258, Issue 5090, pp. 1952-1955

DOI: 10.1126/science.1335167

Field-Weighted Citation Impact: 30.05