Kinetic Studies of the Mechanism of Thrombocytopenia in Patients with Human Immunodeficiency Virus Infection

1992196 citationsJournal Articlebronze Open Access

Authors

Penny Ballem · University of British Columbia

Allan S. Belzberg · University of British Columbia

Dana V. Devine · University of British Columbia

D. Lyster · University of British Columbia

Barry Spruston · St. Paul's Co-educational College

Helen Chambers · St. Paul's Co-educational College

Phillip Doubroff

Abstract

Although there was a moderate reduction in platelet survival in HIV-infected persons, these patients, regardless of platelet counts, also had decreased production of platelets, possibly due to viral infection of the megakaryocytes. Zidovudine appears to improve platelet production.

Topics & Keywords

Blood groups and transfusion Platelet Disorders and Treatments Hemoglobinopathies and Related Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 327, Issue 25, pp. 1779-1784

DOI: 10.1056/nejm199212173272503

Field-Weighted Citation Impact: 4.93