Peptide-Labeled Near-Infrared Quantum Dots for Imaging Tumor Vasculature in Living Subjects

2006944 citationsJournal Article

Authors

Weibo Cai · Stanford University

Dongwoon Shin · Stanford University

Kai Chen · Stanford University

Olivier Gheysens · Stanford University

Qizhen Cao · Stanford University

Shan X. Wang · Stanford University

Sanjiv S. Gambhir · Stanford University

Abstract

We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.

Topics & Keywords

Nanoplatforms for cancer theranostics Advanced biosensing and bioanalysis techniques Quantum Dots Synthesis And Properties

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Nano Letters

Volume 6, Issue 4, pp. 669-676

DOI: 10.1021/nl052405t

Field-Weighted Citation Impact: 62.70