Simvastatin and Niacin, Antioxidant Vitamins, or the Combination for the Prevention of Coronary Disease

20011,985 citationsJournal Articlebronze Open Access

Authors

Bryan Brown

Xue-Qiao Zhao

Alan Chait · Institute of Nutrition, Metabolism and Diabetes

Lloyd D. Fisher · University of Washington

Marian C. Cheung · Institute of Nutrition, Metabolism and Diabetes

Josh S. Morse

Alice Dowdy · Institute of Nutrition, Metabolism and Diabetes

Emily K Marino · University of Washington

Abstract

Simvastatin plus niacin provides marked clinical and angiographically measurable benefits in patients with coronary disease and low HDL levels. The use of antioxidant vitamins in this setting must be questioned.

Topics & Keywords

Lipoproteins and Cardiovascular Health Vitamin C and Antioxidants Research Antioxidant Activity and Oxidative Stress

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 345, Issue 22, pp. 1583-1592

DOI: 10.1056/nejmoa011090

Field-Weighted Citation Impact: 113.78