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A fixed combination of theory-based transport models, called the Multi-Mode Model, is used in the BALDUR [C. E. Singer et al., Comput. Phys. Commun. 49, 275 (1988)] transport simulation code to predict the temperature and density profiles in tokamaks. The choice of the Multi-Mode Model has been guided by the philosophy of using the best transport theories available for the various modes of turbulence that dominate in different parts of the plasma. The Multi-Mode model has been found to provide a better match to temperature and density profiles than any of the other theory-based models currently available. A description and partial derivation of the Multi-Mode Model is presented, together with three new examples of simulations of the Tokamak Fusion Test Reactor (TFTR) [K. M. McGuire et al., Phys. Plasmas 2, 2176 (1995)]. The first simulation shows the strong effect of recycling on the ion temperature profile in TFTR supershot simulations. The second simulation explores the effect of a plasma current ramp—where the plasma energy content changes slowly on the energy confinement time scale. The third simulation shows that the Multi-Mode Model reproduces the experimentally measured profiles when tritium is used as the hydrogenic isotope in L-mode (low confinement mode) plasmas.