The Alteration of Lipid Metabolism in Burkitt Lymphoma Identifies a Novel Marker: Adipophilin

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Authors

Maria Raffaella Ambrosio · University of Siena

Pier Paolo Piccaluga · University of Bologna

Maurilio Ponzoni · San Raffaele University of Rome

Bruno Jim Rocca · University of Siena

Valeria Malagnino · University of Siena

Monica Onorati · University of Siena

Giulia De Falco ·

Abstract

Our preliminary results suggest that lipid metabolism is altered in BL, and this leads to the accumulation of lipid vacuoles. These vacuoles may be specifically recognized by a monoclonal antibody against adipophilin, which may therefore be a useful marker for Burkitt lymphoma because of its peculiar expression pattern. Moreover this peptide might represent an interesting candidate for interventional strategies.

Topics & Keywords

Cancer, Lipids, and Metabolism Lipid metabolism and biosynthesis Cancer, Hypoxia, and Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 7, Issue 8, pp. e44315-e44315

DOI: 10.1371/journal.pone.0044315

Field-Weighted Citation Impact: 1.25