Open Mass Spectrometry Search Algorithm

20041,428 citationsJournal Article

Authors

Lewis Y. Geer · National Institute of Mental Health

Sanford P. Markey · National Center for Biotechnology Information

Jeffrey A. Kowalak · National Institutes of Health

Lukas Wagner · National Institutes of Health

Ming Xu · National Institutes of Health

Dawn Maynard · National Institutes of Health

Xiaoyu Yang

Abstract

Large numbers of MS/MS peptide spectra generated in proteomics experiments require efficient, sensitive and specific algorithms for peptide identification. In the Open Mass Spectrometry Search Algorithm (OMSSA), specificity is calculated by a classic probability score using an explicit model for matching experimental spectra to sequences. At default thresholds, OMSSA matches more spectra from a standard protein cocktail than a comparable algorithm. OMSSA is designed to be faster than published algorithms in searching large MS/MS datasets.

Topics & Keywords

Advanced Proteomics Techniques and Applications Mass Spectrometry Techniques and Applications Metabolomics and Mass Spectrometry Studies

Publication Details

Published in: Journal of Proteome Research

Volume 3, Issue 5, pp. 958-964

DOI: 10.1021/pr0499491

Field-Weighted Citation Impact: 18.10

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Open Mass Spectrometry Search Algorithm

Authors

Abstract

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Publication Details