Bile Acid-Stimulated Expression of the Farnesoid X Receptor Enhances the Immune Response in Barrett Esophagus

200850 citationsJournal Article

Authors

Astrid Capello

Leon M.G. Moons · Haute École de la Province de Liège

Anouk van de Winkel · Haute École de la Province de Liège

Peter D. Siersema · Haute École de la Province de Liège

Herman van Dekken

Ernst J. Kuipers · Erasmus MC

Johannes G. Kusters · Haute École de la Province de Liège

Abstract

Expression levels of the bile acid receptor FXR, the bile acid metabolism genes IBABP and SHP, and the chemokines IL-8 and MIP3 alpha are increased in Barrett's epithelium. The in vitro induction of FXR by DCA suggests that bile acids can actively induce the inflammatory response in BE by recruiting immune cells.

Topics & Keywords

Drug Transport and Resistance Mechanisms Helicobacter pylori-related gastroenterology studies Gastroesophageal reflux and treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The American Journal of Gastroenterology

Volume 103, Issue 6, pp. 1510-1516

DOI: 10.1111/j.1572-0241.2008.01908.x

Field-Weighted Citation Impact: 2.81