A photocleavable affinity tag for the enrichment of alkyne-modified biomolecules

A new photocleavable affinity tag for use in the enrichment of alkyne-labelled biomolecules is reported. The tag is prepared via a concise synthetic route using readily available materials. The photolytic conditions employed for cleavage of the tag provide for a clean release of enriched biomolecules from streptavidin resin.