Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1

2011172 citationsJournal Article

Authors

Ai-Luen Wu

Ganesh Kolumam

Jun Li · Genentech

Scot A. Marsters · Genentech

Lance Kates

Abstract

Antibody-mediated activation of fibroblast growth factor receptor 1 reverses the diabetic phenotype in mice, likely by affecting brown adipose tissues.

Topics & Keywords

Fibroblast Growth Factor Research Cancer, Hypoxia, and Metabolism Kruppel-like factors research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Science Translational Medicine

Volume 3, Issue 113

DOI: 10.1126/scitranslmed.3002669

Field-Weighted Citation Impact: 5.73