Single-Center Experience With Drug-Induced Liver Injury From India: Causes, Outcome, Prognosis, and Predictors of Mortality

2010233 citationsJournal Article

Authors

Harshad Devarbhavi · St.John's Medical College Hospital

Ross Dierkhising · Mayo Clinic

Walter K. Kremers · WinnMed

M. Sandeep · St.John's Medical College Hospital

Dheeraj Karanth · St.John's Medical College Hospital

C. K. Adarsh · St.John's Medical College Hospital

Abstract

DILI results in significant overall mortality (17.3%). ATDs, anti-convulsants, sulphonamides, and olanzapine are the leading causes of DILI. Although common in males, more females developed fulminant hepatic failure. High-MELD score or a combination of ascites, encephalopathy, high bilirubin, prothrombin time, and leukocyte count are predictive of mortality.

Topics & Keywords

Drug-Induced Hepatotoxicity and Protection Pharmacological Effects and Toxicity Studies Drug Transport and Resistance Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The American Journal of Gastroenterology

Volume 105, Issue 11, pp. 2396-2404

DOI: 10.1038/ajg.2010.287

Field-Weighted Citation Impact: 12.18