Rapid responses to anakinra in patients with refractory adult‐onset Still's disease

2005347 citationsJournal Article

Authors

Avril A. Fitzgerald · University of Calgary

Sharon LeClercq · Royal Alexandra Hospital

Alexander Yan · Royal Alexandra Hospital

Charles A. Dinarello · University of Colorado Health

Abstract

Refractory AOSD appears to be IL-1-mediated since anakinra decreases hematologic, biochemical, and cytokine markers and also produces rapid reductions in systemic and local inflammation. Reported efficacy of tumor necrosis factor-blocking therapies in AOSD may be due to a reduction in IL-1.

Topics & Keywords

Autoimmune and Inflammatory Disorders Research Inflammasome and immune disorders Hematological disorders and diagnostics

Publication Details

Published in: Arthritis & Rheumatism

Volume 52, Issue 6, pp. 1794-1803

DOI: 10.1002/art.21061

Field-Weighted Citation Impact: 14.76

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Rapid responses to anakinra in patients with refractory adult‐onset Still's disease

Authors

Abstract

Topics & Keywords

Publication Details