Valproic Acid Monotherapy in Pregnancy and Major Congenital Malformations

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Authors

Janneke Jentink · University of Groningen

Maria Loane · University of Ulster

Helen Dolk · University of Ulster

Ingeborg Barišić · Children's Hospital Zagreb

Ester Garne · Lillebaelt Hospital

Joan K. Morris · Queen Mary University of London

Lolkje T.W. de Jong‐van den Berg

Abstract

The use of valproic acid monotherapy in the first trimester was associated with significantly increased risks of several congenital malformations, as compared with no use of antiepileptic drugs or with use of other antiepileptic drugs.

Topics & Keywords

Pharmacological Effects and Toxicity Studies Pregnancy and Medication Impact Hemoglobinopathies and Related Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 362, Issue 23, pp. 2185-2193

DOI: 10.1056/nejmoa0907328

Field-Weighted Citation Impact: 60.64