Ferrous Sulfate Supplementation Causes Significant Gastrointestinal Side-Effects in Adults: A Systematic Review and Meta-Analysis

2015763 citationsReviewgold Open Access

Authors

Zoe Tolkien · MRC Human Nutrition Research

Dora I. A. Pereira · MRC Human Nutrition Research

Jonathan J. Powell · MRC Human Nutrition Research

Abstract

Our meta-analysis confirms that ferrous sulfate is associated with a significant increase in gastrointestinal-specific side-effects but does not find a relationship with dose.

Topics & Keywords

Esophageal and GI Pathology Intestinal and Peritoneal Adhesions Folate and B Vitamins Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 10, Issue 2, pp. e0117383-e0117383

DOI: 10.1371/journal.pone.0117383

Field-Weighted Citation Impact: 36.04