Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes

2008192 citationsJournal Articlegreen Open Access

Authors

Kim Js · University of Florida

Takashi Nitta · University of Florida

Dagmara Mohuczy · University of Florida

Kerri A. O’Malley · University of Florida

Lyle L. Moldawer · University of Florida

William A. Dunn · University of Florida

K.E. Behrns ·

Abstract

Calpain 2-mediated degradation of Atg7 and Beclin-1 impairs mitochondrial autophagy, and this subsequently leads to MPT-dependent hepatocyte death after A/R.

Topics & Keywords

Autophagy in Disease and Therapy Calpain Protease Function and Regulation Heme Oxygenase-1 and Carbon Monoxide

Publication Details

Published in: Hepatology

Volume 47, Issue 5, pp. 1725-1736

DOI: 10.1002/hep.22187

Field-Weighted Citation Impact: 4.81

Command Palette

Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes

Authors

Abstract

Topics & Keywords

Publication Details