Characteristics of Gintonin-Mediated Membrane Depolarization of Pacemaker Activity in Cultured Interstitial Cells of Cajal

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Authors

Byung Joo Kim · Pusan National University

Joo‐Hyun Nam · Dongguk University

Kyun Ha Kim · Pusan National University

Myungsoo Joo · Pusan National University

Tal Soo Ha · Daegu University

Kwon-Yeon Weon · Catholic University of Daegu

Seok Choi

Abstract

Gintonin-mediated membrane depolarization of pacemaker activity and ANO1 activation are coupled to the stimulation of GI contractility through LPA1/3 receptor signaling pathways in cultured murine ICC. Gintonin might be a ingredient responsible for ginseng-mediated GI tract modulations, and could be a novel candidate for development as a prokinetic agent that may prevent or alleviate GI motility dysfunctions in human patients.

Topics & Keywords

Ion channel regulation and function Ion Channels and Receptors Ion Transport and Channel Regulation

Publication Details

Published in: Cellular Physiology and Biochemistry

Volume 34, Issue 3, pp. 873-890

DOI: 10.1159/000366306

Field-Weighted Citation Impact: 37.66

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Characteristics of Gintonin-Mediated Membrane Depolarization of Pacemaker Activity in Cultured Interstitial Cells of Cajal

Authors

Abstract

Topics & Keywords

Publication Details