Early development of intractable epilepsy in children

2001373 citationsJournal Article

Authors

Anne T. Berg · Albert Einstein College of Medicine

Shlomo Shinnar · Albert Einstein College of Medicine

Simon Lévy · Albert Einstein College of Medicine

Francine M. Testa · Albert Einstein College of Medicine

Susan Smith‐Rapaport · Albert Einstein College of Medicine

Barbara Beckerman · Albert Einstein College of Medicine

Abstract

Approximately 10% of children meet criteria for IE early in the course of their epilepsy. Cryptogenic/symptomatic generalized syndromes carry the highest risk and idiopathic syndromes the lowest. Half of IE occurs in children with nonidiopathic localization-related syndromes. Initial seizure frequency is highly predictive of IE. By contrast, absolute number of seizures and unprovoked or febrile status epilepticus are not.

Topics & Keywords

Epilepsy research and treatment Pharmacological Effects and Toxicity Studies Neonatal and fetal brain pathology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurology

Volume 56, Issue 11, pp. 1445-1452

DOI: 10.1212/wnl.56.11.1445

Field-Weighted Citation Impact: 7.61