Improvement of acquisition and analysis methods in multi-electrode array experiments with iPS cell-derived cardiomyocytes

2015153 citationsJournal Articlehybrid Open Access

Authors

Keiichi Asakura · Gunma University

Seiji Hayashi · Nippon Shinyaku (Japan)

Atsuko Ojima · Eisai (Japan)

Tomohiko Taniguchi · Japan Medical Association

Norimasa Miyamoto · Eisai (Japan)

Chiaki Nakamori · Taisho Pharmaceutical (Japan)

Chiho Nagasawa ·

Abstract

FP can be used to assess the QT prolongation and proarrhythmic potential of drug candidates; however, experimental conditions such as HPF frequency are important for obtaining reliable data.

Topics & Keywords

Neuroscience and Neural Engineering Cardiac electrophysiology and arrhythmias Electrochemical Analysis and Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Pharmacological and Toxicological Methods

Volume 75, pp. 17-26

DOI: 10.1016/j.vascn.2015.04.002

Field-Weighted Citation Impact: 9.82