RNase-L Deficiency Exacerbates Experimental Colitis and Colitis-associated Cancer

201338 citationsJournal Articlebronze Open Access

Authors

Tiha M. Long · University of Maryland, Baltimore

Arindam Chakrabarti · Cleveland Clinic

Heather J. Ezelle · Museum of the American Revolution

Sarah E. Brennan-Laun · Museum of the American Revolution

Jean-Pierre Raufman · University of Maryland, Baltimore

I. V. Polyakova · Cleveland Clinic

Robert H. Silverman

Abstract

RNase-L promotes the innate immune response to intestinal damage and ameliorates murine colitis and colitis-associated cancer. The RNase-L-dependent production of IFN-β stimulated by bacterial RNA may be a mechanism to protect against gastrointestinal inflammatory disease.

Topics & Keywords

interferon and immune responses Cytokine Signaling Pathways and Interactions Immune Response and Inflammation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Inflammatory Bowel Diseases

Volume 19, Issue 6, pp. 1295-1305

DOI: 10.1097/mib.0b013e318281f2fd

Field-Weighted Citation Impact: 1.91