Aetiology and prevention of wound infection in appendicectomy

Abstract A study at the Reading District Hospitals on 451 consecutive patients undergoing appendicectomy through grid-iron incisions sought to determine factors influencing wound infection and the effects of a prophylactic wound-spraying procedure. Wound infection increased with the severity of appendicular inflammation and was well correlated with the degree and nature of bacterial contamination at the time of wound closure. The infection rate was reduced by about one-half when either an aerosol dry-powder formulation of povidone iodine (Disadine D. P.) or an aerosol antibiotic powder spray containing neomycin, bacitracin and polymixin (Dispray) was sprayed on the wound before and after closure. The reduction of infection achieved by spraying with pouidine iodine was statistically significant (P < 0.025). The results of the polyantibiotic spraying did not quite reach significance (P < 0.06). The povidone iodine dry powder was better overall since it reduced infection in all degrees of appendicular inflammation, in all age groups and in enlarged, drained, contaminated and non-contaminated wounds without the attendant disadvantages of antibiotics.