PPARα Activators Inhibit Cytokine-Induced Vascular Cell Adhesion Molecule-1 Expression in Human Endothelial Cells

1999595 citationsJournal Articlebronze Open Access

Authors

Nikolaus Marx · Brigham and Women's Hospital

Galina K. Sukhova · Brigham and Women's Hospital

Tucker Collins · Brigham and Women's Hospital

Peter Libby · Brigham and Women's Hospital

Jorge Plutzky · Brigham and Women's Hospital

Abstract

Human ECs express PPARalpha, a potentially important regulator of atherogenesis through its transcriptional control of VCAM-1 gene expression. Such findings also have implications regarding the clinical use of lipid-lowering agents, like fibric acids, which can activate PPARalpha.

Topics & Keywords

Peroxisome Proliferator-Activated Receptors Blood Coagulation and Thrombosis Mechanisms NF-κB Signaling Pathways

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 99, Issue 24, pp. 3125-3131

DOI: 10.1161/01.cir.99.24.3125

Field-Weighted Citation Impact: 12.68