Disruption of TGF-β Signaling Improves Ocular Surface Epithelial Disease in Experimental Autoimmune Keratoconjunctivitis Sicca

201152 citationsJournal Articlegold Open Access

Authors

Cintia S. de Paiva · Ocular Surface Center

Eugene A. Volpe · Ocular Surface Center

Niral B. Gandhi · Ocular Surface Center

Xiaobo Zhang · Ocular Surface Center

Xiaofen Zheng · Baylor College of Medicine

John D. Pitcher · Ocular Surface Center

William J. Farley ·

Abstract

Our results showed that disruption of TGF-β signaling in CD4(+) T cells causes paradoxical improvement of dry eye disease in mice subjected to desiccating stress.

Topics & Keywords

Ocular Surface and Contact Lens Salivary Gland Disorders and Functions Skin Protection and Aging

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 6, Issue 12, pp. e29017-e29017

DOI: 10.1371/journal.pone.0029017

Field-Weighted Citation Impact: 3.45