Functional Mesenchymal Stem Cells Derived From Human Induced Pluripotent Stem Cells Attenuate Limb Ischemia in Mice

2010613 citationsJournal Articlebronze Open Access

Authors

Qizhou Lian · Chinese University of Hong Kong

Yuelin Zhang · Southern Medical University

Jinqiu Zhang · Chinese University of Hong Kong

Hua Kun Zhang · Southern Medical University

Xingang Wu · Southern Medical University

Yang Zhang · Shenzhen Maternity and Child Healthcare Hospital

Francis Fu-Yuen Lam

Abstract

Functional MSCs can be clonally generated, beginning at a single-cell level, from human iPSCs. Patient-specific iPSC-MSCs can be prepared as an "off-the-shelf" format for the treatment of tissue ischemia.

Topics & Keywords

Mesenchymal stem cell research Pluripotent Stem Cells Research Tissue Engineering and Regenerative Medicine

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 121, Issue 9, pp. 1113-1123

DOI: 10.1161/circulationaha.109.898312

Field-Weighted Citation Impact: 16.27